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A scientific trial has discovered that steady consumption of pink ginseng considerably improves signs of Continual Fatigue Syndrome (CFS). The research was performed by a analysis group led by Professor Dong-Hyuk Jung of the Division of Household Drugs at Yongin Severance Hospital, Yonsei College. The findings had been printed in 2025 within the worldwide peer-reviewed journal Journal of Ginseng Analysis (JGR, Influence Issue: 5.6).
Continual Fatigue Syndrome (CFS) is a posh dysfunction characterised by extreme fatigue lasting for greater than six months with no clear underlying trigger, even after ample relaxation. It’s usually accompanied by “mind fog,” which impairs cognitive capabilities akin to focus and reminiscence, in addition to signs together with sleep disturbances and muscle ache.
Following the worldwide COVID-19 pandemic, the variety of CFS diagnoses has elevated noticeably. Continual fatigue is likely one of the hallmark signs of “lengthy COVID,” a situation during which signs persist lengthy after acute COVID-19 an infection. Based on a research printed within the Journal of Korean Medical Science (JKMS), greater than 55% of COVID-19 sufferers expertise lengthy COVID, with continual fatigue being probably the most prevalent situation, affecting roughly 32% of sufferers.
To research potential interventions, Professor Jung’s group performed a 12-week randomized, double-blind, placebo-controlled scientific trial involving 216 adults aged 35 to 60 who had been identified with COVID-19. The research evaluated modifications in lengthy COVID signs, together with blood checks to evaluate continual irritation markers and immune cell profiles.
The outcomes confirmed that contributors within the pink ginseng group skilled important enhancements in continual fatigue and anxiousness related to lengthy COVID. As well as, reductions in inflammatory markers had been noticed, together with enhancements in immune cell well being—cells that play a essential position in immune system regulation.
Members had been randomly assigned to both a pink ginseng group (n=108) or a placebo group (n=108). Every group consumed 2 grams per day of pink ginseng extract powder or placebo, respectively, for 12 weeks. Assessments had been performed at 3, 6, 9, and 12 weeks utilizing the CFS-COVID19 questionnaire and blood checks measuring continual irritation indicators.
The CFS-COVID19 questionnaire consists of eight gadgets, together with headache, unrefreshing sleep, impaired focus/reminiscence, and anxiousness. Continual Fatigue Syndrome is identified when at the very least 4 standards are met for greater than 12 weeks.
Throughout follow-up, the placebo group confirmed no statistically important change in total CFS-COVID19 scores. In distinction, the pink ginseng group demonstrated a 68% enchancment, with imply scores lowering from 2.78 at baseline to 0.62 after 12 weeks.
Moreover, the ratio of immune helper T cells (CD4) to immune suppressor T cells (CD8)—a marker related to continual irritation and immune growing older—elevated by 35% within the pink ginseng group, whereas no significant change was noticed within the placebo group. Ranges of T cells concerned in suppressing extreme inflammatory responses decreased within the placebo group however had been maintained within the pink ginseng group.
These findings recommend that pink ginseng consumption throughout COVID-19 restoration could assist alleviate signs via immune modulation, supporting symptom enchancment whereas stopping extreme immune responses that contribute to continual irritation.
“By means of this research, we confirmed that steady consumption of pink ginseng can safely and successfully alleviate continual fatigue syndrome, one of the crucial distinguished signs of lengthy COVID,” stated Professor Jung. “Crimson ginseng is anticipated to be useful not just for post-COVID circumstances, but in addition for sufferers affected by long-term sequelae of different viral infections and people with current continual fatigue syndrome.”
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